Description
Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.Blood harmane concentration is elevated in essential tremor, late-life neurological disease.Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.It was used to study interactions of norharman and harman with DNA.It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix